India-Forums

   

NRI scientists find potential colon cancer weapon

Bangalore, Oct 3 (IANS) A five-member team of India-born medical researchers in the United States has discovered what may become a potent new weapon in the fight against colon cancer.

Tuesday, October 3, 2006 | 12:09:10 PM IST (+05:30 GMT)
 0 Comments | By

Bangalore, Oct 3 (IANS) A five-member team of India-born medical researchers in the United States has discovered what may become a potent new weapon in the fight against colon cancer.

The scientists from the University of Texas succeeded in stopping colon cancer growth in mice by halting the activity of a single enzyme called aldose reductase.

Blocking this enzyme shuts down the toxic network of biochemical signals that promotes inflammation and colon cancer cell growth, the scientists reported in the latest issue of journal Cancer Research.

They showed that blocking the production of aldose reductase halts the growth of human colon cancer cells implanted in laboratory mice.

'By inhibiting aldose reductase we were able to completely stop the further growth of colorectal cancer tumour cells,' they said. Colon cancer is the second leading cancer killer in the US.

The team included senior author Satish Srivastava and his colleagues - Ravinder Tammali, Kota V. Ramana, Sharad S. Singhal and Sanjay Awasthi.

In their experiments on mice, the researchers implanted human colon cancer cells beneath the skin of 'nude mice' - a hairless and immune-deficient variety commonly used in medical research.

Tumour progression stopped completely in the mice treated with genetic material known as small interfering RNA (or 'siRNA') that was engineered to prevent cells from making the aldose reductase enzyme.

The treated mice seemed unharmed by the procedure. In contrast, the untreated control animals experienced uncontrolled tumour growth, they reported.

The researchers, however, point out that the gap between a brand new procedure that works in nude mice and one that works in humans is considerable.

Copyright : Indo-Asian News Service
User Rating Rating(0 Votes)

Share On :

Share on Facebook Share on Twitter Share on Google+ Share on WhatsApp

To stay updated with similiar articles follow


User Comments & Ratings

Join India Forums for free to comment on this story. Have an account already? Use Quick Login to comment.
Dear Readers,
  • Please do not use derogatory comments in reply to the stories published on Telly Buzz, India-Forums.
  • The credibility of the site matter to us, and the comments in bad taste tend to invariably hurt the actors/production house/channel etc.
  • So kindly, refrain from creating an unhealthy atmosphere for all, and keep your comments constructive.
  • Also, please use the Rate It button if you want to just thank the author for posting the story.

Articles in National, Diaspora, Health, Sci-Tech

Art - Culture Business Diaspora
Education Health Politics
Religion Sports Sci-Tech
Travel

AROUND THE WORLD NOW

Asia America Australia
Africa Europe Gulf-Middle East
Pakistan Nepal Bhutan
Sri Lanka Bangladesh Maldives

Disclaimer: All Logos and Pictures of various Channels, Shows, Artistes, Media Houses, Companies, Brands etc. belong to their respective owners, and are used to merely visually identify the Channels, Shows, Companies, Brands, etc. to the viewer. Incase of any issue please contact the webmaster.

Popular Channels :
Star Plus | Zee TV | Sony TV | Colors TV | SAB TV | Life OK

Quick Links :
Top 100 TV Celebrities | Top 100 Bollywood Celebs | About Us | Contact Us | Advertise | Forum Index