'Sangharsh' is a story of a research trainee (Preity Zinta) in the CBI, who is offered a dangerous but nevertheless important assignment to track down a psychopath killer who has escaped from the jail and who murders little children as a religious ritual. The only person who can help her reach the killer is in the prison, but this person (Akshay Kumar) is no ordinary mortal. He is a genius and a mind boggling memory. He takes a liking for Preity and vows to help her but only her and not the police force who is also on the trail for the killer. How the girl and the genius succeed in traking down the killer and saving a child in the nick of the time is told in the rest of the story.