Originally posted by -SamiR-
Really enjoying all your answers Vishnu Sa!
btw .. your dodging skills are awesome!
I got a question:
I think you're in research field right? Tell us about your research. Like give us a little abstract.
Also, why did you choose the research field you are in?
o and .. my next thread will be for a VM!
Yeah Samir Ji, I'm quiet enjoying...!! thanks to forum members...!!
Yeah, I'm in research field, and I'm under a new faculty and I'm his 1st Grad student and we are establishing a new lab! So right now I'm ordering things for the lab, a lot of office work going on. Currently making list of chemicals, enzymes and rest for the lab and ordering them! I'll start work only by April only!
Now research! I would ask u to keep a little more geeky here!
I hope you all know a little about CELL.
We have DNA, then it is copied into RNA (Messenger RNA, mRNA) (by protein machinery called RNA polymerase. and known as Transciption), and which is read and coded into proteins (by Ribosome, a large complex consisting both RNA(ribosoal RNA , rRNA) and proteins, and known as Translation.).
The conversions of DNA into RNA and the final product proteins (in general, some RNA stays as such like part of Ribosome, and many other machines in cell) is called Gene Expression.
A gene expression is controlled in many levels.
1, formation of RNA (transcription level).
2, formation of Proteins ( translational level).
3, final degradation of Proetins by Proteosome Complex.
Now the above each step is governed by a huge system which can affect Initiation, Elongation or Stability of each mRNA.
In fact the Viruses utilizes the intricate mechanisms in above regulations to fool our cell, and cell fight back using the way they evolve to fool our system. So a Pathogen and Host co-evolve each other.
Now there are intricate small RNA copied from DNA of final proceed length called microRNA (miRNA) which bind to end sequences of a messenger RNA (mRNA) and destabilize the mRNA (its mechanism varies in plants and animals, though they share many commonalities).
Now anything that is formed in a cell needs to be targeted to degradation after use, or needs to be diverted for other purposes. Many molecules in cell do dual or multitasking and thus conserving energy.
We would be working in finding molecules and mechanisms involved in the micro RNA degradation. and How they are diverted in to doing other purposes other than messenger RNA destabilization.
And our model system is a worm! called Ceanorhabditis elegans. or C. elegans.
A GIF image from Wiki
Its ideal since small and can be grown in small petri plates. and it reproduces faster, and is a hermaphrodite (only 2 sexes, male which is minor <5%, and hermaphrodite).
And last but not the least its TRANPARENT!! and each cell has been counted its position been attributed. In fact how single cell give rise to each is recorded.
You may further read it simply from Wiki if interested.
(my research is under the title miRNA Turn Over!)
I know the above been a lecture, but believe me its more complicated!!! and I'm glad to know about ur next thread...!!