Love life, enjoy life and live life to the fullest — that's exactly the mindset of the four central characters of Raffoo Chakkar- fun on the run. Pappu (Yudhishtir), Munnu (Aslam Khan), known as PM are twin brothers (born same day). Millie (Nauheed Cyrusi) and Julie (Nisha Rawal), known as MJ are sisters from the upper crust of society. All of them believe in enjoying their life to the fullest and are not interested in getting married. But the unbelievable happens. When forced to get married they run away from their homes.
While on the run lots of fun happens. Pappu and Munnu meet and get attracted to the cute looking Millie and Julie. Naturally they try to woo the girls, not realizing that they are the same girls with whom their fathers had fixed their marriage. Another twist comes in the story when Millie and Julie meet Kokila and Koena (KK), two middle-aged sisters who hate men and never want to get married.
Fate takes another turn and KK's father, who wants his daughters to get married, dies, leaving his entire property in the hands of trustrees managed by Dilkhush (Sadashiv Amrapurkar) and Hansmukh (Shakti Kapoor) making a will which has a catch.
P M, who are on the run, are broke and need money as they have promised an expensive gift for the girls MJ on their birthday. Having no options left they land up at KK's house to rob them but they are in for a surprise. The middle aged girls are Judo/Karate champions and catch the boy's red handed. All hell breaks loose.
By now MJ now are in love. What follows is a plan by PM Brothers to murder KK to get rid of their old wives. There is confusion all around which leads to a very hilarious unfolding of the entire story.