In the 1996 film, Karisma played Aarti, a rich but simple girl, who falls in love with Raja, a local taxi driver.
"Sometimes I always think with 'Raja Hindustani', you would want to know what happened between Raja and Aarti because it culminated at the marriage point. So it would be interesting and that (movie) has a story line to go forward," Karisma told IANS.
Both Aamir and Karisma had won the Filmfare best actor and best actress award for the movie.
"We as actors should look at it like that (added responsibility). We should do a film because the role might inspire the audience and what basically matters is your audience should love you and love your film," the 38-year-old said.
Karisma had recently made a comeback with Vikram Bhatt's "Dangerous Ishhq", which didn't fare too well at the box office.